Inhibition of DNA methyltransferase leads to increased genomic 5‐hydroxymethylcytosine levels in hematopoietic cells
نویسندگان
چکیده
1 Institute of Enzymology, RCNS, HAS, Budapest, Hungary 2 Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary 3 MS Metabolomics Laboratory, Core Facility, RCNS HAS, Budapest, Hungary 4 MTA-SE NAP-B Molecular Psychiatry and in vitro Disease Modeling Research Group, Budapest, Hungary 5 Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary 6 CNRS UMR 6214, INSERM U1083, University of Angers, Angers, France
منابع مشابه
TET2 Inhibits Differentiation of Embryonic Stem Cells but Does Not Overcome Methylation-Induced Gene Silencing
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متن کاملInhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
TET2 converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA and is frequently mutated in myeloid malignancies, including myeloproliferative neoplasms. Here we show that the level of 5-hmC is decreased in granulocyte DNA from myeloproliferative neoplasm patients with TET2 mutations compared with granulocyte DNA from healthy patients. Inhibition of TET2 by RNA interference decreases ...
متن کاملO-11: N-a-acetyltransferase 10 Protein Regulates DNA Methylation and Embryonic Development
Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2018